Berberine Improves Depression‐Like Behaviors and Gastrointestinal Dysfunction in 6‐Hydroxydopamine‐Induced Parkinson's Disease Rats
These findings suggested that BBR ameliorated the colonic dysfunction in 6-OHDA rats and modulated changes in enteric neurotransmitters and EGCs. Moreover, BBR regulated monoamines in the midbrain and OXA and CRF in the hypothalamus, which are associated with depression-like behaviors in 6-OHDA rats. This study provides a theoretical and experimental foundation for the potential application of BBR in treating non-motor symptoms of PD.
Authors
- Song Jin (ORCID: https://orcid.org/0000-0002-4513-4622)
- Li‐Fei Zheng
- Xiaohong Yu (ORCID: https://orcid.org/0000-0003-2352-2023)
- Jin‐Xia Zhu (ORCID: https://orcid.org/0000-0002-9478-3290)
- Caifeng Zhang
- Yue Zhang (ORCID: https://orcid.org/0000-0002-5826-5621)
- Xiaoli Zhang (ORCID: https://orcid.org/0000-0002-0770-5594)
- Yuli Sun (ORCID: https://orcid.org/0000-0001-9227-2924)
- Zi‐Ming Liu
- Tianze Zhang
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- China Rehabilitation Research Center (CN)
- Beijing Jishuitan Hospital (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1111/nmo.70033
- Citations
- 1
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China