TP53-centric ctDNA complements PET/CT for non-invasive assessment of pathological complete response and survival after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma: a prospective cohort study
The combination of post-treatment TP53 -centric ctDNA and PET/CT synergistically enhances the prediction of pCR following NICT in ESCC patients, indicating the potential to inform clinical decision-making for these patients.
Authors
- Shuishen Zhang (ORCID: https://orcid.org/0000-0002-5029-708X)
- Bo Zeng
- Weixiong Yang (ORCID: https://orcid.org/0000-0002-6916-8253)
- Sicong Ma (ORCID: https://orcid.org/0000-0001-5894-5910)
- Chao Cheng (ORCID: https://orcid.org/0000-0003-3571-8154)
- Qiuxiang Ou (ORCID: https://orcid.org/0000-0002-2961-2057)
- Zengli Fang
- Junchao Cai (ORCID: https://orcid.org/0000-0001-8412-6177)
- Sai‐Ching J. Yeung (ORCID: https://orcid.org/0000-0001-5170-0822)
- Fang Wang (ORCID: https://orcid.org/0000-0003-0871-780X)
- Lingling Yang (ORCID: https://orcid.org/0000-0003-1149-3237)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-3499-2189)
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0002-8763-289X)
- Zhenguo Liu (ORCID: https://orcid.org/0000-0002-4510-1599)
- Yao Liu (ORCID: https://orcid.org/0000-0001-5682-0313)
- Yuze Wang (ORCID: https://orcid.org/0000-0002-8575-3508)
- Chenxuan Wang (ORCID: https://orcid.org/0000-0001-6045-7908)
- Hui Luo (ORCID: https://orcid.org/0000-0003-2527-0237)
- Wenfang Chen (ORCID: https://orcid.org/0000-0003-3263-1096)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1097/js9.0000000000002341
- Citations
- 3
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.02