Determining the Usefulness of Selected Laboratory Markers of Inflammation in Qualifying Patients for <scp>T2</scp> Biosystems Determination

A single analysis of parameters such as C-reactive protein (CRP), white blood cells (WBC), #neutr, #lymph, and neutrophil-to-lymphocyte ratio (NLR) is not a good indicator that could be used as an additional tool facilitating patient qualification for T2Dx testing. The most sensitive parameter distinguishing between patients with a positive T2Dx result and those with a negative result is the measurement of IL-6 and PCT. Proper patient qualification for T2Dx testing can significantly contribute to reducing the time to initiate targeted antibiotic therapy and may impact reducing mortality and improving long-term treatment outcomes.

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Publication Details

Journal
Journal of Clinical Laboratory Analysis
Published
2025-03-27
DOI
https://doi.org/10.1002/jcla.70021
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Determining the Usefulness of Selected Laboratory Markers of Inflammation in Qualifying Patients for T2 Biosystems Determination

Małgorzata M. Skiba, Mateusz Szymański, Małgorzata Piasecka
Journal of Clinical Laboratory Analysis
Sepsis Diagnosis and Treatment
article

Determining the Usefulness of Selected Laboratory Markers of Inflammation in Qualifying Patients for T2 Biosystems Determination

Małgorzata M. Skiba, Mateusz Szymański, Małgorzata Piasecka
article en

Abstract

A single analysis of parameters such as C-reactive protein (CRP), white blood cells (WBC), #neutr, #lymph, and neutrophil-to-lymphocyte ratio (NLR) is not a good indicator that could be used as an additional tool facilitating patient qualification for T2Dx testing. The most sensitive parameter distinguishing between patients with a positive T2Dx result and those with a negative result is the measurement of IL-6 and PCT. Proper patient qualification for T2Dx testing can significantly contribute to reducing the time to initiate targeted antibiotic therapy and may impact reducing mortality and improving long-term treatment outcomes.

Journal of Clinical Laboratory AnalysisVol. 39(8)
Medical University of Lublin (PL), Cardinal Stefan Wyszynski University in Warsaw (PL)
Openalex Percentile: Top 91%
Sepsis Diagnosis and Treatment
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