Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson’s disease
Quercetin alleviates Parkinson's disease pathology by inhibiting neuroinflammation, reducing apoptosis, and activating the PI3K/Akt/GSK-3β pathway. These findings underscore its potential as a multi-target therapeutic agent for Parkinson's disease.
Authors
- Jiao Zhao (ORCID: https://orcid.org/0000-0001-5446-1388)
- Minghao Man
- Gang Zhao (ORCID: https://orcid.org/0000-0002-2405-3372)
- Yiyuan Tian (ORCID: https://orcid.org/0000-0002-7479-0960)
- FengZhou Liu
- Wei‐Tien Chang (ORCID: https://orcid.org/0000-0002-1880-7932)
- Songya Huang (ORCID: https://orcid.org/0000-0002-2979-4057)
- Y. Li (ORCID: https://orcid.org/0009-0002-0512-2202)
- Junhui Xue
Institutions
- Kunming Medical University (CN)
- Air Force Engineering University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Tang Du Hospital (CN)
- Xijing Hospital (CN)
- South China University of Technology (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Inflammopharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1007/s10787-025-01712-2
- Citations
- 8
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- National Natural Science Foundation of China
- Shanxi Provincial Key Research and Development Project