Imaging Cell Surface Plectin in PDAC Patients – A First-In-Human Phase 0 Study Report
PTP-01 imaging of pancreatic tumors revealed the ability of a targeted agent to bind to CSP. Further, CSP density in tumors was estimated to be on par with other surface molecules such as Her2 with effective targeted therapies. This study suggests that CSP is a highly expressed, accessible molecule for the development of targeted therapies such as antibodies or antibody-drug conjugates.
Authors
- Jiang He (ORCID: https://orcid.org/0000-0001-7600-4604)
- Reid B. Adams (ORCID: https://orcid.org/0009-0007-0687-0567)
- Julien Dimastromatteo (ORCID: https://orcid.org/0000-0001-5406-5182)
- Kimberly M. Kelly (ORCID: https://orcid.org/0000-0002-7006-3862)
Institutions
- University of Virginia (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1007/s11307-025-02001-8
- Citations
- 4
- Primary Topic
- Skin and Cellular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- Division of Cancer Prevention, National Cancer Institute