Validation of a cancer population derived AKI machine learning algorithm in a general critical care scenario

Applying our algorithm to MIMIC data generated an AUROC of 0.821 (95% CI 0.820-0.821) per blood test. Our cancer derived algorithm compares positively with other AKI models derived and/or tested on MIMIC, with our model predicting AKI at the longest time frame of up to 30 days. This suggests that our model can achieve a good performance on patient cohorts very different to those from which it was derived, demonstrating the transferability and applicability for implementation in a clinical setting.

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Publication Details

Journal
Clinical & Translational Oncology
Published
2025-03-26
DOI
https://doi.org/10.1007/s12094-025-03906-0
Primary Topic
Acute Kidney Injury Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Validation of a cancer population derived AKI machine learning algorithm in a general critical care scenario

Catherine O’Hara, Lauren Scanlon, Matthew Barker-Hewitt, Jorge Barriuso
Clinical & Translational Oncology
Acute Kidney Injury Research
article

Validation of a cancer population derived AKI machine learning algorithm in a general critical care scenario

Catherine O’Hara, Lauren Scanlon, Matthew Barker-Hewitt, Jorge Barriuso
article en

Abstract

Applying our algorithm to MIMIC data generated an AUROC of 0.821 (95% CI 0.820-0.821) per blood test. Our cancer derived algorithm compares positively with other AKI models derived and/or tested on MIMIC, with our model predicting AKI at the longest time frame of up to 30 days. This suggests that our model can achieve a good performance on patient cohorts very different to those from which it was derived, demonstrating the transferability and applicability for implementation in a clinical setting.

Clinical & Translational OncologyVol. 27(9)
University of Manchester (GB), Cancer Research UK Manchester Institute (GB), The Christie NHS Foundation Trust (GB)
Cancer Research UK
Good health and well-being
Openalex Percentile: Top 92%
Acute Kidney Injury Research
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