Validation of a cancer population derived AKI machine learning algorithm in a general critical care scenario
Applying our algorithm to MIMIC data generated an AUROC of 0.821 (95% CI 0.820-0.821) per blood test. Our cancer derived algorithm compares positively with other AKI models derived and/or tested on MIMIC, with our model predicting AKI at the longest time frame of up to 30 days. This suggests that our model can achieve a good performance on patient cohorts very different to those from which it was derived, demonstrating the transferability and applicability for implementation in a clinical setting.
Authors
- Catherine O’Hara
- Lauren Scanlon (ORCID: https://orcid.org/0000-0001-7380-7145)
- Matthew Barker-Hewitt
- Jorge Barriuso (ORCID: https://orcid.org/0000-0002-5641-9105)
Institutions
- University of Manchester (GB)
- Cancer Research UK Manchester Institute (GB)
- The Christie NHS Foundation Trust (GB)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1007/s12094-025-03906-0
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research UK