A cross‐tissue transcriptome‐wide association study reveals novel susceptibility genes for erectile dysfunction
This comprehensive cross-tissue TWAS analysis identified LCLAT1 as a primary susceptibility gene for ED, highlighting its potential role in the mitochondrial function and lipid metabolism. The study also revealed several secondary candidate genes that may contribute to ED through pathways related to mitochondrial dynamics, neurotransmission, and cardiovascular function. These findings provide new perspectives on the genetic architecture of ED and suggest potential targets for future research and treatment.
Authors
- Jingjing Gao (ORCID: https://orcid.org/0000-0003-4226-3944)
- Junhua Du
- Tianle Zhu (ORCID: https://orcid.org/0000-0002-2816-0175)
- Xiansheng Zhang (ORCID: https://orcid.org/0000-0001-6003-5182)
- Hui Jiang (ORCID: https://orcid.org/0000-0002-6256-2733)
- Yukuai Ma (ORCID: https://orcid.org/0009-0000-8479-6779)
- Pan Gao (ORCID: https://orcid.org/0000-0003-0973-7845)
- Peng Yang (ORCID: https://orcid.org/0009-0005-3739-5047)
- Z.P. Cao (ORCID: https://orcid.org/0009-0007-0426-4643)
Institutions
- Anhui Medical University (CN)
- Peking University (CN)
- Peking University First Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Andrology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1111/andr.70034
- Citations
- 2
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- University Natural Science Research Project of Anhui Province