Surgical treatment of ophthalmological complications in patients with Lyell’s syndrome

Lyell’s syndrome is a severe disease, a toxic-allergic reaction occurring in 0.3 % of cases of drug allergies. Currently, Lyell's syndrome is considered as a proteolytic reaction with damage to the skin and mucous membranes. Ophthalmological complications observed in patients with Lyell's syndrome are described. During the disease and treatment of pneumonia, a corneal ulcer with perforation appeared in both eyes, which was not relieved by drug treatment. The patients underwent keratoplasty with biological corneal coating according to Kuhnt and bloody blepharorrhea, which made it possible to stop the inflammatory process. Remote consequences of eye damage that have undergone toxic epidermal necrolysis syndrome lead to severe cicatricial-dystrophic changes in the eyelids, conjunctiva and cornea, decreased vision, even if the intraocular media may remain transparent, and the retina is intact. The issue of rehabilitation of patients who have suffered toxic epidermal necrolysis is relevant. This research describes the treatment of the consequences of eye damage in Lyell’s syndrome (elimination of symblepharon, entropion and trichiasis).