Triglyceride-rich lipoprotein sphingolipids are altered in primary hypertension: A pilot case-control study
Patients with hypertension display higher plasma Cer levels than normotensive controls, which is mainly explained by elevated concentrations in TRLs. Cer levels positively correlate with systolic and diastolic blood pressure, and ratios of Cer relative to Cer(d18:1/24:0) suggest an increased cardiovascular risk.
Authors
- Edith C. H. Friesema (ORCID: https://orcid.org/0000-0001-7743-1907)
- Jeanine E. Roeters van Lennep (ORCID: https://orcid.org/0000-0001-6870-9962)
- Mardin Rashid
- Melvin Lafeber (ORCID: https://orcid.org/0000-0001-7061-6415)
- Leonie C van der Zee-van Vark
- Adrie J.M. Verhoeven (ORCID: https://orcid.org/0000-0002-6767-4208)
- Sandra den Hoedt (ORCID: https://orcid.org/0000-0002-9209-4029)
- Gardi Voortman
- Fazil Alidjan
- Christina Christoffersen (ORCID: https://orcid.org/0000-0003-3751-5203)
- Kristien Y. Dorst‐Lagerwerf
- Monique Mulder
Institutions
- University of Copenhagen (DK)
- European Organisation for Research and Treatment of Cancer (NL)
- Erasmus MC (NL)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of clinical lipidology
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.jacl.2025.03.014
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00