Features of central aortic pressure at patients with arterial hypertension aged 80 years and older, taking into account the presence of chronic heart failure and senile asthenia syndrome

Objective: to evaluate the parameters of central aortic pressure in patients with arterial hypertension (AH) depending on the presence of chronic heart failure (CHF) and senile asthenia syndrome (SSA). Materials and methods: 320 patients with AH were divided into four groups: group 1A — patients with AH, SSA and CHF (n=84), group 1B — patients with AH, SSA without CHF (n=84), group 2A — patients with AH, CHF without SSA (n=77), group 2B — patients with AH without CHF and without SSA (n=75). Central aortic pressure parameters were determined using a BPLab ABPM device using Vasotens technology (“Petr Telegin”, Nizhny Novgorod). To process the obtained data, statistical programs STATISTICA 12.0, SPSS 21.0, MedCalc 9.3.5.0 were used. Results: in patients with AH, CHF and SSA, higher average daily values of SBP ao were recorded compared to both patients with AH and CHF without SSA (p=0.004) and with AH, SSA without CHF (p=0.019). The presence of SSA led to higher AIx ao values both in patients with hypertension, SSA and CHF (p<0.001), and in patients with AH and SSA without CHF (p<0.001). In patients with AH and CHF, regardless of the presence of SSA, higher rates of PBP ao (p<0.001), AIx ao (p<0.001), ED (p<0.001) and lower rates of SERV (p<0.001) were recorded. When assessing the degree of influence of CHF or SSA, it was shown that CHF had a more pronounced effect on PBP ao (p<0.001), ED (p<0.001) and SERV (p<0.001) indicators than SSA. Conclusion: in patients with AH aged 80 years and older, the development of both SSA and, to a greater extent, the presence of CHF was accompanied by an increase in central aortic pressure. With a combination of AH, CHF and SSA, the most pronounced disturbances in the elastic properties of blood vessels were observed, which is associated with a high cardiovascular risk.