The Toxicity Profile of Pemetrexed in Non-Small Cell Lung Cancer Patients With Moderate Renal Impairment: A Retrospective Cohort Study
Pemetrexed treatment of NSCLC patients with moderate renal impairment was associated with high incidence of hematological toxicity, hospitalization, dose reduction, and treatment discontinuation. These results highlight the necessity of developing new treatment regimens to enable safe pemetrexed-based immunochemotherapy in NSCLC patients with renal impairment.
Authors
- Fenna de Vries (ORCID: https://orcid.org/0009-0001-3993-2898)
- Mart P. Kicken (ORCID: https://orcid.org/0000-0002-5321-0816)
- Rob ter Heine (ORCID: https://orcid.org/0000-0003-2185-8201)
- Frank Eektimmerman (ORCID: https://orcid.org/0000-0002-9358-2294)
- Albert J. Polman
- Cor H. van der Leest
- Nikki de Rouw (ORCID: https://orcid.org/0000-0002-1991-0552)
- Tim Beerden
- Nienke A. G. Lankheet (ORCID: https://orcid.org/0000-0002-7237-9908)
- L. L. Krens (ORCID: https://orcid.org/0000-0003-3842-9585)
- Michel M. van den Heuvel (ORCID: https://orcid.org/0000-0002-6372-2153)
- Eric J. F. Franssen (ORCID: https://orcid.org/0000-0002-1506-0730)
- Arthur A J Smit
- Bas Peters (ORCID: https://orcid.org/0009-0004-1321-3969)
- Maarten J. Deenen (ORCID: https://orcid.org/0000-0002-4389-6420)
- Ben E.E.M. van den Borne
- John W.G. van Putten
- L.C. Vermeer (ORCID: https://orcid.org/0009-0005-9350-2361)
- Intissar Azarfane
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Radboud University Medical Center (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Amphia Ziekenhuis (NL)
- Maasstad Ziekenhuis (NL)
- Martini Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
Publication Details
- Journal
- Clinical Lung Cancer
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.cllc.2025.03.010
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52