Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events
Disclosure of an integrated risk score that included a polygenic risk score to individuals at intermediate risk for CHD was associated with lower MACE incidence after 10 years, likely due to higher statin initiation, leading to lower low-density lipoprotein cholesterol levels.
Authors
- Kristján Norland (ORCID: https://orcid.org/0009-0009-3418-119X)
- Kent R. Bailey (ORCID: https://orcid.org/0000-0001-8968-643X)
- Azin Teymourzadeh (ORCID: https://orcid.org/0000-0001-9159-8287)
- Iftikhar J. Kullo (ORCID: https://orcid.org/0000-0002-6524-3471)
- Marwan Hamed (ORCID: https://orcid.org/0000-0003-1299-9969)
- Mohammadreza Naderian (ORCID: https://orcid.org/0000-0003-1827-3173)
- Ozan Dikilitas (ORCID: https://orcid.org/0000-0002-9906-8608)
- Ali A. Vaseem
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1161/circgen.124.004968
- Citations
- 5
- Primary Topic
- Health Systems, Economic Evaluations, Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 15.66