Insight into antistaphylococcal effect of chlorinated 1-hydroxy-naphthalene-2-carboxanilides
From the set of tested mono-, di- and trisubstituted derivatives, it is evident that the position of chlorine atoms is decisive for significant antistaphylococcal activity. Inhibition of energy metabolism does not appear to be one of the main mechanisms of action of compound <b>10</b>; on the contrary, the antibacterial effect may likely be contributed by downregulation of proteins (especially ATP-dependent protease ATPase subunit HslU) involved in processes essential for bacterial survival and growth, such as protein, nucleotide/nucleic acid synthesis and efficient protein repair/degradation.
Authors
- Tereza Kauerová (ORCID: https://orcid.org/0000-0003-2854-511X)
- Jiří Kos (ORCID: https://orcid.org/0000-0002-3589-4361)
- Josef Jampílek (ORCID: https://orcid.org/0000-0003-2003-9052)
- Tomáš Goněc (ORCID: https://orcid.org/0000-0003-3712-8641)
- Petra Majerová (ORCID: https://orcid.org/0000-0001-9239-6425)
- Alois Čížek (ORCID: https://orcid.org/0000-0001-5706-4601)
- Péter Kollár (ORCID: https://orcid.org/0000-0003-2265-1528)
- Andrej Kováč (ORCID: https://orcid.org/0000-0002-3223-8705)
- Dominika Pindjaková (ORCID: https://orcid.org/0000-0001-7994-313X)
- Lucia Vrablova
Institutions
- University of Veterinary Sciences Brno (CZ)
- Slovak Academy of Sciences (SK)
- Masaryk University (CZ)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- Comenius University Bratislava (SK)
- University of Silesia in Katowice (PL)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2025-03-26
- DOI
- https://doi.org/10.5599/admet.2684
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Centre for Genetic Engineering and Biotechnology
- Agentúra na Podporu Výskumu a Vývoja