Saikosaponin A targets HDAC6 to inhibit Mycobacterium tuberculosis-induced macrophage Pyroptosis via autophagy-mediated NLRP3 inflammasome inactivation
SSA targets HDAC6 and exerts an immunomodulatory effect, highlighting its potential as a promising novel host-directed anti-tuberculosis agent.
Authors
- Fanglin Liu (ORCID: https://orcid.org/0000-0002-8371-6316)
- Yaqi Liu
- Yuejuan Zheng (ORCID: https://orcid.org/0000-0001-9995-4960)
- Jianchao Wu
- Jingjing Shen (ORCID: https://orcid.org/0000-0003-4360-7585)
- Xin Jiang (ORCID: https://orcid.org/0000-0001-7007-0483)
- Jinxia Sun (ORCID: https://orcid.org/0000-0003-2006-3765)
- Hemin Zhang (ORCID: https://orcid.org/0000-0001-7599-3869)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.phymed.2025.156693
- Citations
- 3
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality