Soufeng Sanjie formula alleviates the progression of lupus and joint injury by regulating the ALKBH5-FoxO1-PFKFB3 axis in M-MDSCs
This study confirmed that SF enhanced glycolysis in M-MDSCs by regulating the ALKBH5-FoxO1-PFKFB3 axis, which decreased Th17 cells and alleviated lupus and joint injury. These data firstly indicate SF may represent a potential treatment option for SLE and joint damage, revealing regulatory effects of DP, the key active component of SF, at the post-transcriptional level.
Authors
- Huan Dou (ORCID: https://orcid.org/0000-0001-6330-398X)
- Peng Cao (ORCID: https://orcid.org/0000-0002-2044-3074)
- Yayi Hou (ORCID: https://orcid.org/0000-0002-1152-9132)
- Tian-Shu Zhang (ORCID: https://orcid.org/0000-0002-8934-3311)
- Lingyu Zhang (ORCID: https://orcid.org/0000-0002-4297-903X)
- Zehua Wu (ORCID: https://orcid.org/0000-0001-7088-9982)
- Liping Tan (ORCID: https://orcid.org/0000-0002-1773-0435)
- Shuangan Wang
- Xiuzhu Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.phymed.2025.156687
- Citations
- 6
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 9.34