Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence
This study identifies SAA2 as a potential therapeutic target for osteoarthritis and suggests that Vaccarin presents a promising treatment avenue.
Authors
- Hao Kang (ORCID: https://orcid.org/0000-0003-3670-9946)
- Yongqiao Jiang
- Guanghao Li (ORCID: https://orcid.org/0009-0000-3095-9990)
- Jinrong Min (ORCID: https://orcid.org/0000-0001-5210-3130)
- Mingbo Nie
- Hui Huang (ORCID: https://orcid.org/0000-0001-8599-7441)
- Yunqian Zeng (ORCID: https://orcid.org/0009-0004-3108-120X)
- Xin Chen (ORCID: https://orcid.org/0000-0003-3668-4830)
- Jianwen Li (ORCID: https://orcid.org/0000-0001-5959-9861)
- Xin Gan (ORCID: https://orcid.org/0009-0002-5518-2254)
- Xiaohui Wang (ORCID: https://orcid.org/0009-0006-5575-8603)
Institutions
- Wuhan Institute of Virology (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-03-28
- DOI
- https://doi.org/10.1016/j.phymed.2025.156697
- Citations
- 7
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 11.68
Funders
- National Natural Science Foundation of China
- Nanchang University