Fecal microbiota transplantation modulates myeloid-derived suppressor cells and attenuates renal fibrosis in a murine model
FMT enhances M-MDSC-mediated immunomodulation, reducing inflammation and renal fibrosis in UUO-induced CKD. These findings suggest a potential therapeutic strategy targeting the gut-kidney axis in CKD management.
Authors
- Xiao Zhang (ORCID: https://orcid.org/0000-0003-2547-7262)
- Yuhan Cao (ORCID: https://orcid.org/0000-0001-8830-7768)
- Yuye Chen (ORCID: https://orcid.org/0000-0002-3749-6594)
- Yuanhui Shi (ORCID: https://orcid.org/0000-0002-1147-5410)
- Cong Fu (ORCID: https://orcid.org/0000-0002-4306-0594)
- Yajie Wang (ORCID: https://orcid.org/0000-0003-3404-3319)
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1080/0886022x.2025.2480749
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province