Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism
Patients with IBS-D exhibited low-grade inflammation in the colon mucosal tissues, compromised intestinal barrier function, and abnormal visceral sensation. This may be attributed to the decreased levels of tryptophan indole metabolites, the heightened activity of enteric glial cells (EGCs), and the inhibition of AHR/CPY1A1 signaling pathway.
Authors
- Fei Dai (ORCID: https://orcid.org/0000-0001-8992-3079)
- Laifu Li
- Ran Yan (ORCID: https://orcid.org/0000-0002-6152-9683)
- Xiaojing Quan (ORCID: https://orcid.org/0000-0002-1020-6657)
- Lin Mei (ORCID: https://orcid.org/0000-0003-2822-835X)
- Yue Zhang (ORCID: https://orcid.org/0000-0003-2128-8472)
- Ting Wang (ORCID: https://orcid.org/0000-0003-4510-2134)
- Yating Sun (ORCID: https://orcid.org/0009-0000-6446-1525)
- Haitao Shi (ORCID: https://orcid.org/0000-0003-2354-5209)
- Lianli Wang
- F Ye
Institutions
- Xi'an Honghui Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-03-28
- DOI
- https://doi.org/10.3389/fnut.2025.1566595
- Citations
- 5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Natural Science Foundation of China