Seminal plasma induces receptivity-associated genes and pathways in endometrial epithelial organoids
Seminal plasma induces a complex and diverse molecular response in EEO. Despite this variability, a consistent expression pattern of 105 genes was observed among all EEO, including genes associated with endometrial receptivity and the (mid)secretory phase. This suggests that seminal plasma may stimulate a more receptive-like phenotype in EEO in the absence of progesterone or its derivatives. This study underscores the importance of understanding male‒female reproductive crosstalk and the need to identify regulatory components in seminal plasma to improve the outcomes of assisted reproduction technology.
Authors
- Gaby S. Steba (ORCID: https://orcid.org/0000-0003-2652-0760)
- Willem Verpoest (ORCID: https://orcid.org/0000-0002-5020-2888)
- Frank J. Broekmans (ORCID: https://orcid.org/0000-0003-1366-2727)
- Matthijs S. Abendroth (ORCID: https://orcid.org/0009-0004-4350-3449)
- Brigitte Arends (ORCID: https://orcid.org/0009-0006-0573-5972)
- J Berg (ORCID: https://orcid.org/0000-0002-0522-9993)
- Marguerite Toros
- Yuwei Zhang (ORCID: https://orcid.org/0000-0001-8927-3184)
Institutions
- University Medical Center Utrecht (NL)
Publication Details
- Journal
- Reproductive BioMedicine Online
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1016/j.rbmo.2025.104982
- Citations
- 3
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Merck
- Merck KGaA
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek