Maternal platelet-derived factors induce trophoblastic LAIR2 expression to promote trophoblast invasion and inhibit platelet activation at the fetal-maternal interface
This study suggests that maternal platelet-derived factors affect the transcriptional profile of trophoblasts, including upregulation of LAIR2, which may be involved in fine-tuning the coagulation of maternal blood leaking from eroded decidual blood vessels and could increase the invasiveness of EVTs into the decidua through an autocrine mechanism.
Authors
- Beate Rinner (ORCID: https://orcid.org/0000-0002-6340-4905)
- Julian Krappinger (ORCID: https://orcid.org/0000-0002-8855-087X)
- Joanna L. James (ORCID: https://orcid.org/0000-0002-3757-4177)
- Gerit Moser (ORCID: https://orcid.org/0000-0002-9917-0629)
- Juergen Pollheimer
- Martin Gauster (ORCID: https://orcid.org/0000-0003-0386-6857)
- Julia Feichtinger (ORCID: https://orcid.org/0000-0002-3667-5857)
- Daniela S. Valdes (ORCID: https://orcid.org/0000-0002-1309-5147)
- Anna-Lena Höbler (ORCID: https://orcid.org/0000-0001-5529-9378)
- Gerhard Cvirn (ORCID: https://orcid.org/0000-0002-1410-1844)
- Christine Daxboeck
- Nadja Kupper (ORCID: https://orcid.org/0000-0003-1586-1914)
- Djenana Vejzovic
- Florian Herse (ORCID: https://orcid.org/0000-0002-9305-8134)
- Kaja Ujčič
- Daniel Kummer (ORCID: https://orcid.org/0009-0008-5576-8945)
- Désirée Forstner (ORCID: https://orcid.org/0000-0001-5451-7580)
- Freya Lyssy
- Stefan Wernitznig (ORCID: https://orcid.org/0000-0002-8547-5456)
- Lena Neuper
- Amin El‐Heliebi (ORCID: https://orcid.org/0000-0002-7679-6856)
- Jacqueline Guettler
Institutions
- University of Auckland (NZ)
- Medical University of Graz (AT)
- Max Delbrück Center (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1016/j.jtha.2025.03.020
- Citations
- 1
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Deutsche Forschungsgemeinschaft
- Austrian Science Fund
- Karl-Franzens-Universität Graz
- Medizinische Universität Graz