Neurons Form GABAergic Synapses that Promote Diffuse Midline Glioma

Major Finding: Neuron-to-tumor GABAergic synapses promote tumor cell depolarization and proliferation in H3K27M-mutant diffuse midline glioma (DMG).Concept: Stimulated interneurons fire action potentials that lead to postsynaptic currents which drive DMG progression.Impact: This study nominates GABA as a key neurotransmitter that influences DMG growth and prompts further investigation into the use of benzodiazepines in DMG patient care.