Estrogen receptor α suppresses hepatocellular carcinoma by restricting M2 macrophage infiltration through the YAP-CCL2 axis
ERα/YAP/CCL2 signaling reduced M2 macrophages infiltration to inhibit HCC progression, revealing the effect of ERα in cancer cells on immune cells in HCC microenvironment.
Authors
- Dan He (ORCID: https://orcid.org/0000-0002-0118-3625)
- Zhiyu Wang (ORCID: https://orcid.org/0000-0002-0606-318X)
- Zijie Li (ORCID: https://orcid.org/0000-0002-5618-1862)
- Dehua Wang (ORCID: https://orcid.org/0000-0001-5626-736X)
- Ting-Ting Lv
- Xiaokuan Zhang (ORCID: https://orcid.org/0000-0002-3114-6251)
Institutions
- Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Fifth Hospital of Shijiazhuang (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s12885-025-13676-1
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30