Dosimetric analysis of beam number variations in IMRT for head-and-neck, breast, and pelvic cancers using Halcyon
This study investigated the dosimetric effects of varying beam numbers (9, 11, and 13) in intensity-modulated radiation therapy (IMRT) using the Halcyon linear accelerator at ShingMark University Hospital. IMRT plans for 27 patients with head-and-neck, breast, and pelvic cancers were evaluated according to the RTOG 0615 protocol, focusing on Planning Target Volume (PTV) dose coverage, uniformity, maximum and minimum doses, and Organ-at-Risk (OAR) dose constraints. For breast cancer, the 11-beam plan improved PTV coverage (V50Gy: 97.9 ± 0.5 %) and reduced maximum dose compared to 9- and 13-beam plans, while the 13-beam plan lowered heart mean dose by up to 10.5 % in left breast cases. In pelvic cases, the 13-beam plan enhanced OAR sparing, reducing bowel V35Gy by 10.5 % compared to the 9-beam plan, with minimal PTV coverage differences (<0.2 %). For head-and-neck cancer, the 13-beam plan improved PTV D95 % and spared critical structures like the brainstem, though it increased doses to the chiasm and cochlea. Treatment time and Monitor Units rose with more beams, particularly for head-and-neck and pelvic cases, but remained minimal for breast cases. These findings suggest tailoring beam numbers to cancer type and clinical priorities, balancing dosimetric benefits with treatment efficiency. • Evaluates the dosimetric impact of beam number variations in IMRT for multiple cancer sites. • Compares 9-, 11-, and 13-beam IMRT plans using the Halcyon linear accelerator. • Assesses dose conformity, homogeneity, and organ-at-risk sparing efficiency. • Provides clinical recommendations for optimizing IMRT planning strategies. • Contributes to personalized radiotherapy approaches in modern treatment settings.
Authors
- Sitti Yani (ORCID: https://orcid.org/0000-0002-4761-6561)
- Abdelmoneim Sulieman (ORCID: https://orcid.org/0000-0003-0830-4706)
- Dương Thanh Tài (ORCID: https://orcid.org/0000-0001-7276-8105)
- Nissren Tamam (ORCID: https://orcid.org/0000-0001-9709-2754)
- James C. L. Chow (ORCID: https://orcid.org/0000-0003-4202-4855)
- Peter Sandwall (ORCID: https://orcid.org/0000-0001-9962-7281)
- Luong Tien Phat (ORCID: https://orcid.org/0009-0004-0963-1922)
- Tran Trung Kien
- Mai Thi Thao
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- University Health Network (CA)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- University of Toronto (CA)
- IPB University (ID)
- King Faisal Specialist Hospital & Research Centre (SA)
- Princess Margaret Cancer Centre (CA)
- Trường ĐH Nguyễn Tất Thành (VN)
- OhioHealth Mansfield Hospital (US)
- Hanoi Medical University Hospital (VN)
- Pham Ngoc Thach Hospital (VN)
Publication Details
- Journal
- Radiation Physics and Chemistry
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1016/j.radphyschem.2025.112755
- Citations
- 4
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 7.53
Funders
- Princess Nourah Bint Abdulrahman University