Investigating the Relationship Between Tumor Cells, Healthy Tissue, and an Active Immune System in a Mathematical Model of Cancer Cell Growth

Analyzing tumor growth dynamics improves treatment strategies for cancer. Many models have been proposed to analyze cancer development dynamics, which do not always exhibit chaotic behavior. This research aims to create and examine a unique dynamical cancer model that exhibits chaotic behavior for certain parameters. Introducing chaos into the model allows for the exploration of irregular tumor growth patterns and the identification of critical thresholds that can influence treatment outcomes. The model is examined, and each system parameter’s impact on the model’s dynamics is evaluated. The analysis of the bifurcation and Lyapunov diagrams demonstrates chaos in three populations of tumor, healthy, and immune system cells. By suppressing the immunological response, the cancer cell gains control of the chaotic attractor and establishes a stable state. This might lower the cancer condition by altering the appropriate parameter range assisting in tumor treatment.

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Publication Details

Journal
International Journal of Bifurcation and Chaos
Published
2025-03-26
DOI
https://doi.org/10.1142/s0218127425500646
Primary Topic
Mathematical Biology Tumor Growth
Type
article
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article

Investigating the Relationship Between Tumor Cells, Healthy Tissue, and an Active Immune System in a Mathematical Model of Cancer Cell Growth

Fatemeh Parastesh, P. Vafaei, Mahdieh Ghasemi, Ali Foroutannia et al.
International Journal of Bifurcation and Chaos
Mathematical Biology Tumor Growth
article

Investigating the Relationship Between Tumor Cells, Healthy Tissue, and an Active Immune System in a Mathematical Model of Cancer Cell Growth

Fatemeh Parastesh, P. Vafaei, Mahdieh Ghasemi, Ali Foroutannia, Fatemeh Halaji
article en

Abstract

Analyzing tumor growth dynamics improves treatment strategies for cancer. Many models have been proposed to analyze cancer development dynamics, which do not always exhibit chaotic behavior. This research aims to create and examine a unique dynamical cancer model that exhibits chaotic behavior for certain parameters. Introducing chaos into the model allows for the exploration of irregular tumor growth patterns and the identification of critical thresholds that can influence treatment outcomes. The model is examined, and each system parameter’s impact on the model’s dynamics is evaluated. The analysis of the bifurcation and Lyapunov diagrams demonstrates chaos in three populations of tumor, healthy, and immune system cells. By suppressing the immunological response, the cancer cell gains control of the chaotic attractor and establishes a stable state. This might lower the cancer condition by altering the appropriate parameter range assisting in tumor treatment.

International Journal of Bifurcation and ChaosVol. 35(06)
University of Neyshabur (IR), SRM Institute of Science and Technology (IN), Easwari Engineering College, Ferdowsi University of Mashhad (IR)
Good health and well-being
Openalex Percentile: Top 93%
Mathematical Biology Tumor Growth
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Investigating the Relationship Between Tumor Cells, Healthy Tissue, and an Active Immune System in a Mathematical Model of Cancer Cell Growth — Fatemeh Parastesh, P. Vafaei, et al. · International Journal of Bifurcation and Chaos (2025) | TGRS Research Map | TGRS