Spatial relationships and interactions of immune cell niches are linked to the pathologic response of muscle-invasive bladder cancer to neoadjuvant therapy
This study underscores the critical role of TLS formation in the response to neoadjuvant therapy in MIBC. We identified CCL19/CCL21 as key drivers of TLS formation within MIBC tumors and potential immune-sensitizing agents. Additionally, the intrinsic heterogeneity of tumor should be considered a significant factor influencing therapeutic efficacy.
Authors
- Xihua Yang (ORCID: https://orcid.org/0000-0002-5990-2186)
- Wasilijiang Wahafu (ORCID: https://orcid.org/0000-0002-6306-2079)
- Xiongjun Ye (ORCID: https://orcid.org/0000-0001-9012-2869)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0003-0440-1170)
- Nianzeng Xing (ORCID: https://orcid.org/0000-0002-2696-5279)
- Xiangpeng Kang
- Zhu Wang (ORCID: https://orcid.org/0000-0002-5457-3731)
- Yongming Yang (ORCID: https://orcid.org/0000-0002-8816-2500)
- Quan Zhou (ORCID: https://orcid.org/0000-0002-8856-5836)
Institutions
- Shanxi Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Cancer Center (US)
- Shanxi Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s12967-025-06358-w
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.02