Using in vivo calcium imaging to examine joint neuron spontaneous activity and home cage analysis to monitor activity changes in mouse models of arthritis
Group-housed home cage monitoring revealed locomotor changes in AIA mice, but not PMX mice (with n = 10/group). In vivo calcium imaging can be used to assess activity in multiple retrogradely labelled joint afferents and revealed increased spontaneous activity in AIA but not PMX mice.
Authors
- Carl Hobbs
- George L. Goodwin (ORCID: https://orcid.org/0000-0003-2146-5520)
- Franziska Denk (ORCID: https://orcid.org/0000-0003-4883-4234)
- Julia M. Vlachaki Walker (ORCID: https://orcid.org/0000-0002-7545-1549)
- Alina-Cristina Marin
Institutions
- King's College London (GB)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s13075-025-03515-w
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- Wellcome Trust
- UK Research and Innovation
- Medical Research Council