Gut Microbial Metabolite Imidazole Propionate Impairs Endothelial Cell Function and Promotes the Development of Atherosclerosis
Our findings reveal a hitherto unknown role of the microbially produced histidine-derived metabolite ImP in endothelial dysfunction and atherosclerosis, suggesting that ImP metabolism is a potential therapeutic target in atherosclerotic cardiovascular disease.
Authors
- Pegah Ramezani Rad (ORCID: https://orcid.org/0000-0002-6697-9149)
- David M. Leistner (ORCID: https://orcid.org/0000-0002-4351-420X)
- Marcus Henricsson (ORCID: https://orcid.org/0000-0002-4202-0339)
- C. Weber (ORCID: https://orcid.org/0000-0002-7676-1223)
- Arash Haghikia (ORCID: https://orcid.org/0000-0002-5646-3237)
- Elisabeth Strässler (ORCID: https://orcid.org/0000-0002-5286-9686)
- Stanley L. Hazen (ORCID: https://orcid.org/0000-0001-7124-6639)
- N Kraenkel (ORCID: https://orcid.org/0000-0002-9363-1770)
- Ina Nemet (ORCID: https://orcid.org/0000-0002-0657-7121)
- Fredrik Bäckhed (ORCID: https://orcid.org/0000-0002-4871-8818)
- Wolfgang M. Kuebler (ORCID: https://orcid.org/0000-0003-4100-2961)
- Michael Potente (ORCID: https://orcid.org/0000-0002-5689-0036)
- Yvonne Döring (ORCID: https://orcid.org/0000-0001-9307-3396)
- Lisa Peters (ORCID: https://orcid.org/0000-0003-3157-6590)
- Jakob Steinfeldt (ORCID: https://orcid.org/0000-0003-1387-2054)
- Maximilian König (ORCID: https://orcid.org/0000-0003-4873-5519)
- Ilja Demuth (ORCID: https://orcid.org/0000-0002-4340-2523)
- Petra Knaus (ORCID: https://orcid.org/0000-0003-2492-1667)
- Katharina R. Beck (ORCID: https://orcid.org/0000-0001-9818-1265)
- Leander Reinshagen
- Ulf Landmesser (ORCID: https://orcid.org/0000-0002-0214-3203)
- Vanasa Nageswaran (ORCID: https://orcid.org/0000-0002-4738-2558)
- Barbara J. H. Verhaar (ORCID: https://orcid.org/0000-0001-7941-6110)
- J.J. Lim (ORCID: https://orcid.org/0000-0002-1740-8710)
- Marc Ferrell (ORCID: https://orcid.org/0000-0002-2460-5659)
- Elisabeth Steinhagen–Thiessen
- Max Nieuwdorp
- Alba Carreras (ORCID: https://orcid.org/0000-0001-8787-8833)
Institutions
- Goethe University Frankfurt (DE)
- University of Bern (CH)
- St. Michael's Hospital (CA)
- Bern University of Applied Sciences (CH)
- Cleveland Clinic (US)
- University of Toronto (CA)
- Max Delbrück Center (DE)
- Universitätsmedizin Greifswald (DE)
- Maastricht University Medical Centre (NL)
- University Hospital of Bern (CH)
- Sahlgrenska University Hospital (SE)
- Cleveland Clinic Lerner College of Medicine (US)
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- Amsterdam Neuroscience (NL)
- Munich Cluster for Systems Neurology (DE)
- Max Planck Institute for Human Development (DE)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- German Center for Lung Research (DE)
- University Hospital Frankfurt (DE)
- St. Josef-Hospital (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Amsterdam University Medical Centers (NL)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1161/atvbaha.124.322346
- Citations
- 23
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 18.54
Funders
- Västra Götalandsregionen
- Cleveland Clinic
- Case Western Reserve University
- School of Medicine, Case Western Reserve University
- University of Bern
- Deutsches Zentrum für Herz-Kreislaufforschung
- Inselspital, Universitätsspital Bern
- Amsterdam University Medical Centers
- Universiteit Maastricht
- University of Toronto
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet
- Humboldt-Universität zu Berlin
- Freie Universität Berlin
- Deutsches Zentrum für Lungenforschung
- Berlin-Brandenburg School for Regenerative Therapies
- Berlin Institute of Health
- Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers