Gut Microbial Metabolite Imidazole Propionate Impairs Endothelial Cell Function and Promotes the Development of Atherosclerosis

Our findings reveal a hitherto unknown role of the microbially produced histidine-derived metabolite ImP in endothelial dysfunction and atherosclerosis, suggesting that ImP metabolism is a potential therapeutic target in atherosclerotic cardiovascular disease.

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Publication Details

Journal
Arteriosclerosis Thrombosis and Vascular Biology
Published
2025-03-27
DOI
https://doi.org/10.1161/atvbaha.124.322346
Citations
23
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
18.54

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article

Gut Microbial Metabolite Imidazole Propionate Impairs Endothelial Cell Function and Promotes the Development of Atherosclerosis

Pegah Ramezani Rad, David M. Leistner, Marcus Henricsson, C. Weber et al.
23 citations
Arteriosclerosis Thrombosis and Vascular Biology
Gut microbiota and health
18.54
article

Gut Microbial Metabolite Imidazole Propionate Impairs Endothelial Cell Function and Promotes the Development of Atherosclerosis

Pegah Ramezani Rad, David M. Leistner, Marcus Henricsson, C. Weber, Arash Haghikia, Elisabeth Strässler, Stanley L. Hazen, N Kraenkel, Ina Nemet, Fredrik Bäckhed, Wolfgang M. Kuebler, Michael Potente, Yvonne Döring, Lisa Peters, Jakob Steinfeldt, Maximilian König, Ilja Demuth, Petra Knaus, Katharina R. Beck, Leander Reinshagen, Ulf Landmesser, Vanasa Nageswaran, Barbara J. H. Verhaar, J.J. Lim, Marc Ferrell, Elisabeth Steinhagen–Thiessen, Max Nieuwdorp, Alba Carreras
article en
23 citations

Abstract

Our findings reveal a hitherto unknown role of the microbially produced histidine-derived metabolite ImP in endothelial dysfunction and atherosclerosis, suggesting that ImP metabolism is a potential therapeutic target in atherosclerotic cardiovascular disease.

Arteriosclerosis Thrombosis and Vascular BiologyVol. 45(5)
Goethe University Frankfurt (DE), University of Bern (CH), St. Michael's Hospital (CA), Bern University of Applied Sciences (CH), Cleveland Clinic (US), University of Toronto (CA), Max Delbrück Center (DE), Universitätsmedizin Greifswald (DE), Maastricht University Medical Centre (NL), University Hospital of Bern (CH), Sahlgrenska University Hospital (SE), Cleveland Clinic Lerner College of Medicine (US), Humboldt-Universität zu Berlin (DE), Deutsches Herzzentrum der Charité (DE), Amsterdam Neuroscience (NL), Munich Cluster for Systems Neurology (DE), Max Planck Institute for Human Development (DE), Berlin-Brandenburger Centrum für Regenerative Therapien (DE), German Centre for Cardiovascular Research (DE), German Center for Lung Research (DE), University Hospital Frankfurt (DE), St. Josef-Hospital (DE), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Amsterdam University Medical Centers (NL), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE), Ludwig-Maximilians-Universität München (DE), Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Västra Götalandsregionen, Cleveland Clinic, Case Western Reserve University, School of Medicine, Case Western Reserve University, University of Bern, Deutsches Zentrum für Herz-Kreislaufforschung, Inselspital, Universitätsspital Bern, Amsterdam University Medical Centers, Universiteit Maastricht, University of Toronto, Sahlgrenska Universitetssjukhuset, Göteborgs Universitet, Humboldt-Universität zu Berlin, Freie Universität Berlin, Deutsches Zentrum für Lungenforschung, Berlin-Brandenburg School for Regenerative Therapies, Berlin Institute of Health, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers
Good health and well-being
Openalex Percentile: Top 0%
Gut microbiota and health
18.54
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