Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility
These results suggest that hABCC4 can bind cAMP and exhibits varying degrees of flexibility when binding with different substrates, including cAMP. These findings expand our understanding of the structural biology of ABCC4.
Authors
- Weiming Tian (ORCID: https://orcid.org/0000-0002-2183-0519)
- Xin Wen (ORCID: https://orcid.org/0000-0003-4864-8255)
- Kaixue Si (ORCID: https://orcid.org/0000-0003-4463-7882)
- Anqi Zhang (ORCID: https://orcid.org/0000-0001-5128-2464)
- Changyou Guo
- Minghui Li (ORCID: https://orcid.org/0000-0002-8941-1329)
- Dantong Zhu
Institutions
- Harbin Institute of Technology (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s13578-025-01377-y
- Citations
- 3
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Harbin Institute of Technology