Effect of Salmonella Dublin latent carrier dry cow vaccination on bacterial shedding and intrauterine transmission

Salmonella Dublin latent carrier cows pose a significant risk for transmitting infection to newborn calves through intra-uterine transmission and bacterial shedding in feces and colostrum at calving. Vaccination of these latent carriers’ dams during late gestation can enhance the immunity against S. Dublin. This could reduce the activation of the dormant bacterium during the periparturient immune dysfunction period, thereby reduc­ing the risk of early-life infection in the offspring until vacci­nation is possible. This study aimed to evaluate the extent to which vaccinating S. Dublin latent carrier cows at dry-off with a commercial live bacterial vaccine (EnterVene®-d, Boehringer Ingelheim) reduces bacterial shedding at calving and intrauter­ine infection in calves.