The molecular properties of the bHLH TCF4 protein as an intrinsically disordered hub transcription factor
We suggest that bHLH plays the role of an anchor localizing TCF4 to specific gene sequences. The dual nature of the TCF4 structure and the fact that the intrinsically disordered regions (IDRs) represent most of the protein sequence, suggest that TCF4 may act as a hub transcription factor regulating the expression of specific genes through the interaction of IDRs with gene-specific partners.
Authors
- Michał Dadlez (ORCID: https://orcid.org/0000-0001-8811-5176)
- Beata Greb‐Markiewicz (ORCID: https://orcid.org/0000-0002-2831-439X)
- Lilia Zhukova (ORCID: https://orcid.org/0000-0001-8607-2918)
- Nikola Sozańska (ORCID: https://orcid.org/0000-0001-6635-1768)
- Anna Niedźwiecka (ORCID: https://orcid.org/0000-0001-5208-0733)
- Aneta Tarczewska (ORCID: https://orcid.org/0000-0003-2209-0919)
- Andrzej Ożyhar (ORCID: https://orcid.org/0000-0002-5874-784X)
- Barbara P. Klepka (ORCID: https://orcid.org/0000-0002-4496-8713)
Institutions
- Wrocław University of Science and Technology (PL)
- Institute of Physics (PL)
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
- AGH University of Krakow (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s12964-025-02154-7
- Citations
- 2
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Narodowe Centrum Nauki