Moringa oleifera L. Leaf Extract as Wound Dressing on Collagen Formation in Burn Wounds

Background: Burns are damage to organic skin tissue due to thermal exposure. According to Indonesia’s Research Institute (2018), the incidence of burns in 2018 were 1,701 cases. The long healing time and inappropriate treatment methods are the causes of the high mortality rate of burns. The use of Bioplacenton as a conventional medicine for burns have relatively expensive prices, limited availability, and reaps pros and cons regarding its halal status. Moringa leaves can be an alternative in the treatment of burns because they contain secondary metabolism such as flavonoids, saponins, tannins, and alkaloids that can accelerate the wound healing process. The large natural potential it has is also one of the advantages in the use of Moringa leaves. Objective: To determine the effectiveness of wound dressing gel extract of Moringa leaves (Moringa oleifera L.) on collagen formation in the healing of burns in male Wistar rats (Rattus Norvegicus). Method: The study used a quasi-experimental design in vivo category post control group design with a quantitative approach. The research sample of 15 mice that met the inclusion and exclusion criteria were divided into 5 groups, namely the positive control group (Bioplacenton), the negative control group (Basis gel), the Moringa extract treatment group 10%, 20%. And 40%. Results: Data analysis obtained the results of the Shapiro-Wilk test showing a sig value> 0.05 which means the data is normally distributed, then continued with the One-way ANOVA test obtained a sig value> 0.05 with the results showing no significant value between groups so that the post hoc test was not necessary. Conclusion: Administration of Moringa leaf extract gel does not provide significant effectiveness on the formation of collagen density in healing burns in experimental animals. Keywords: Moringa Leaves, Burn Wounds, Gel Leaf Extract