Association of ASAP1 Gene Polymorphisms (rs4733781 and rs10956514) with Tuberculosis Susceptibility in the Kaluku Bodoa Makassar Population, Indonesia

Background: Tuberculosis (TB) remains a significant global health challenge, with genetic factors playing a role in determining an individual’s susceptibility to the disease. Objective: This study investigated the association between ASAP1 gene polymorphisms (rs4733781 and rs10956514) and TB susceptibility in the Kaluku Bodoa Makassar community, Indonesia. Methods: A case-control study involved 85 subjects (45 TB patients and 40 healthy controls) from the Kaluku Bodoa Makassar population. DNA samples were extracted, and genotyping was performed using multiplex PCR and purification methods. Results: The results revealed a significant association between ASAP1 gene polymorphisms rs4733781 (C/A allele) and rs10956514 (A/G allele) and increased TB susceptibility (P<0.05). Individuals carrying these alleles exhibited a higher risk of developing TB compared to controls. These findings suggest that genetic variation in ASAP1 contributes to TB pathogenesis in this population. Conclusion: Further research is needed to elucidate the biological mechanisms and potential applications in TB screening and treatment strategies. Further studies are needed to explore the biological mechanisms underlying the association between ASAP1 gene polymorphisms and TB susceptibility and to develop more effective diagnostic and therapeutic strategies for pulmonary TB based on individual genetic profiles.