Quality of life in patients with end-stage chronic kidney disease and sarcopenia

Aim. To perform a correlation analysis between QoL scales and diagnostic indicators of sarcopenia in CKD stage 5 (CKD5) patients, determined using bioimpedance spectroscopy (BIS) for body composition assessment. Materials and Methods. The study included 182 CKD5 patients residing in the Kemerovo Region. Sarcopenia was diagnosed in 56 patients according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. To assess QoL, we applied a dialysis-specific Kidney Disease Quality of Life Short Form ((KDQOL-SF) version 1.3 and sarcopenia-specific Sarcopenia Quality of Life (SarQoL) questionnaires. Results. In patients with sarcopenia and CKD5, the KDQOL-SF questionnaire showed low scores with regards to the following specific scales: CKD burden (60 [53.75; 70.0]), cognitive functions (61.1 [50.0; 66.67]), quality of social interaction (66.67 [55.56; 73.61]), quality of sleep (60.71 [57.14; 64.29]) and general perception of health (60 [50; 60]). The SarQoL questionnaire demonstrated low QoL scores in the following domains: physical and mental health (61 [54; 71]), locomotion (68 [65; 68]), body composition (45 [30; 45]), leisure activities (50 [50; 50]). A moderate and statistically significant positive correlation was identified between the Short Physical Performance Battery (SPPB) and the following domains: daily activities (r = 0.66), functionality (r = 0.72), body composition (r = 0.65), and physical and mental health (r = 0.66). Conclusion. Correlations were identified between SPPB scores and three specific scales of the KDQOL-SF questionnaire (symptoms/problems, cognitive function, and quality of social interaction), as well as five domains of the SarQoL questionnaire (leisure activities, activities of daily living, functionality, body composition, physical and mental health).