Population pharmacokinetic analysis of intravenous voriconazole in cancer patients
The findings suggest that this model can be used for dosage adjustment based on creatinine clearance and primary diagnosis as they impact significantly on voriconazole clearance in cancer patients. This approach is especially valuable in resource-limited settings like Pakistan, where individualized therapy can enhance the safety and efficacy of antifungal treatment, addressing the unique clinical and demographic challenges in vulnerable populations.
Authors
- Zunaira Akbar (ORCID: https://orcid.org/0000-0002-7592-8677)
- Abdulwahab Alamri (ORCID: https://orcid.org/0000-0001-8852-7517)
- Mohammed Salem Alharbi (ORCID: https://orcid.org/0000-0002-1456-9287)
- Zikria Saleem (ORCID: https://orcid.org/0000-0003-3202-6347)
- Muhammad Rehan Khan (ORCID: https://orcid.org/0000-0002-6110-583X)
- Muhammad Salman Aamir (ORCID: https://orcid.org/0000-0002-4471-676X)
- Gamal Osman (ORCID: https://orcid.org/0000-0002-6041-6206)
- Muhammad Usman (ORCID: https://orcid.org/0000-0003-4854-1888)
Institutions
- Bahauddin Zakariya University (PK)
- University of Lahore (PK)
- Riphah International University (PK)
- University of Ha'il (SA)
- Shaukat Khanum Memorial Cancer Hospital and Research Center (PK)
- University of Veterinary and Animal Sciences (PK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1371/journal.pone.0318883
- Citations
- 1
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 1.40