Copper-Catalyzed Triyne Cyclization via Vinyl Cations
Herein, we describe an efficient copper-catalyzed cyclization of triynes via vinyl cation intermediates. The reaction leads to the practical and atom-economical synthesis of valuable polycyclic pyrroles by constructing three new rings in one step under mild reaction conditions. The proposed reaction mechanism shows the ordered and regioselective reaction of alkynes. Moreover, the possibility of such an asymmetric triyne cyclization also emerges.
Authors
- Feng‐Lin Hong
- Long‐Wu Ye (ORCID: https://orcid.org/0000-0003-3108-2611)
- Zhou Xu (ORCID: https://orcid.org/0000-0002-9703-8245)
- Yan-Xin Zheng
- Binju Wang (ORCID: https://orcid.org/0000-0002-3353-9411)
- Guanghui Wang (ORCID: https://orcid.org/0000-0001-8551-6468)
- Chen Luo (ORCID: https://orcid.org/0000-0002-9365-6409)
- Shengbiao Ji
- Hongmei Song (ORCID: https://orcid.org/0000-0002-8369-310X)
Institutions
- Xuzhou Medical College (CN)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Organic Chemistry (CN)
- State Key Laboratory of Chemical Engineering (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1021/acs.orglett.5c00769
- Citations
- 4
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Jiangsu Province
- Xuzhou Science and Technology Program