Comparative efficacy of Pirfenidone and Meloxicam on early radiotherapy-induced anal sphincter dysfunction in rats
This study demonstrates that Pirfenidone, either as monotherapy or in combination with Meloxicam, mitigates radiation-induced fibrotic remodeling and preserves anal sphincter function. However, the combination therapy did not provide an additive benefit over Pirfenidone alone. These findings highlight Pirfenidone as a promising therapeutic strategy for managing post-radiotherapy sphincter dysfunction. Further research is needed to elucidate the underlying molecular mechanisms and optimize antifibrotic and myoprotective interventions for clinical application in cancer survivors.
Authors
- Irina-Draga Căruntu (ORCID: https://orcid.org/0000-0002-0104-8503)
- Dragoş Viorel Scripcariu (ORCID: https://orcid.org/0000-0002-9945-6328)
- Mitică Ciorpac (ORCID: https://orcid.org/0000-0001-5374-0908)
- Radu Iliescu (ORCID: https://orcid.org/0000-0002-9124-577X)
- Bogdan-Ionel Tamba (ORCID: https://orcid.org/0000-0001-9868-1999)
- Andrei Szilagyi (ORCID: https://orcid.org/0009-0009-4734-4509)
- Ludmila Lozneanu (ORCID: https://orcid.org/0000-0002-3994-6579)
- Teodora Alexa‐Stratulat (ORCID: https://orcid.org/0000-0003-2696-9568)
- Bogdan Ionuţ Dobrovăț (ORCID: https://orcid.org/0000-0001-9571-2630)
- Andrei Daniel Timofte (ORCID: https://orcid.org/0000-0001-7905-9221)
- Lucian Eva (ORCID: https://orcid.org/0000-0003-2478-7437)
- Cezar Cătălin Caratașu
- Cristian Răzvan Buga
Institutions
- Grigore T. Popa University of Medicine and Pharmacy (RO)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fphar.2025.1441011
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00