Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia (m-RESIST) Solution for Improving Clinical and Functional Outcomes in Treatment-Resistant Schizophrenia: Prospective, Multicenter Efficacy Study
To our best knowledge, this was the first study to address the efficacy of the mHealth app m-RESIST on the symptoms and functional capacity and on the quality of life for people with TRS. Our preliminary findings showed that implementing the m-RESIST solution decreased the symptoms and severity of disease, and improved the functionality and perceived quality of life among those with TRS. The change of symptoms on the PANSS total may be clinically significant. Modern technologies such as mHealth interventions may be useful in treating symptoms and functionality even in TRS, which is a major clinical challenge, with usually poor outcomes. These results should be corroborated by performing a controlled trial.
Authors
- Judith Usall (ORCID: https://orcid.org/0000-0002-1746-7737)
- Katya Rubinstein (ORCID: https://orcid.org/0000-0003-2875-4456)
- Zsolt Unoka (ORCID: https://orcid.org/0000-0003-0103-5064)
- Jesús Berdún (ORCID: https://orcid.org/0000-0002-5955-9920)
- Susana Ochoa (ORCID: https://orcid.org/0000-0001-6792-1080)
- Alexandra Roldán (ORCID: https://orcid.org/0000-0001-9905-3943)
- Cari Almazán (ORCID: https://orcid.org/0000-0001-8556-0792)
- Marianne Haapea (ORCID: https://orcid.org/0000-0002-3989-9354)
- Asaf Caspi (ORCID: https://orcid.org/0000-0003-1205-6557)
- Erika Jääskeläinen (ORCID: https://orcid.org/0000-0001-5760-7389)
- Kinga Farkas (ORCID: https://orcid.org/0000-0002-1125-3957)
- Anna Alonso-Solís (ORCID: https://orcid.org/0000-0002-5393-9391)
- Iluminada Corripio (ORCID: https://orcid.org/0000-0003-2562-711X)
- Jussi Seppälä (ORCID: https://orcid.org/0000-0002-8752-2041)
- Johanna Caro Mendivelso
- Eva Grasa (ORCID: https://orcid.org/0000-0003-1100-7489)
- Jouko Miettunen (ORCID: https://orcid.org/0000-0003-0575-2669)
- Elisenda Reixach (ORCID: https://orcid.org/0000-0001-8557-0771)
- Matti Isohanni (ORCID: https://orcid.org/0000-0002-3692-8228)
Institutions
- Semmelweis University (HU)
- Generalitat de Catalunya (ES)
- Oulu University Hospital (FI)
- Social Insurance Institution (FI)
- Sheba Medical Center (IL)
- Hospital de Sant Pau (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Althaia (ES)
- Agència de Qualitat i Avaluació Sanitàries de Catalunya (ES)
- Parc Sanitari Sant Joan de Déu (ES)
- University of Oulu (FI)
Publication Details
- Journal
- JMIR Human Factors
- Published
- 2025-03-27
- DOI
- https://doi.org/10.2196/67659
- Primary Topic
- Digital Mental Health Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Horizon 2020 Framework Programme