Celastrol reduces cisplatin-induced nephrotoxicity by downregulating SNORD3A level in kidney organoids derived from human iPSCs
This study highlights the potential of celastrol as a protective compound against cisplatin-induced kidney damage and emphasizes the importance of using advanced models, such as iPSC-derived kidney organoids, to predict therapeutic effect and nephrotoxic concentrations of novel drugs.
Authors
- Ming You (ORCID: https://orcid.org/0000-0002-7051-6825)
- Xun Ye
- Chunjie Wu (ORCID: https://orcid.org/0000-0001-7496-8469)
- Yiqing Zhou (ORCID: https://orcid.org/0000-0002-4553-5207)
- Chengjie Pan
- Chia‐Ning Shen (ORCID: https://orcid.org/0000-0002-0747-217X)
- Qizheng Wang (ORCID: https://orcid.org/0000-0001-9126-8050)
- Heying Li (ORCID: https://orcid.org/0009-0006-5025-8941)
- Huayang Xing (ORCID: https://orcid.org/0009-0007-9455-3296)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Bank of China (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fphar.2025.1464525
- Citations
- 1
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.81