Itraconazole resistance in Madurella fahalii linked to a distinct homolog of the gene encoding cytochrome P450 14-α sterol demethylase (CYP51)
We demonstrated that itraconazole resistance in M. fahalii may be attributed to the presence of an additional CYP51 gene. This study represents the first report on the physiological characteristics of Madurella species using genetic engineering techniques.
Authors
- Isato Yoshioka (ORCID: https://orcid.org/0000-0001-7449-2771)
- Satoshi Kaneko (ORCID: https://orcid.org/0000-0001-9464-0911)
- Ahmed Hassan Fahal (ORCID: https://orcid.org/0000-0003-4922-7321)
- Takashi Yaguchi (ORCID: https://orcid.org/0000-0002-9697-8470)
- Wei Cao (ORCID: https://orcid.org/0000-0001-5628-7918)
Institutions
- University of Khartoum (SD)
- Waseda University (JP)
- Chiba University Hospital (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1371/journal.pntd.0012623
- Citations
- 1
- Primary Topic
- Actinomycetales infections and treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.04
Funders
- Japan Agency for Medical Research and Development