Anti-inflammatory and anti-diabetic activity of N1-(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium (E)-3-(4-hydroxy-3-methoxyphenyl)acrylates

A series of nine N 1 -(4-substitutedbenzyl/butyl)-2-methyl-4-nitro-1 H -imidazoles ( 3a-i ) and their N 1 -(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium ( E )-3-(4-hydroxy-3-methoxyphenyl)acrylates ( IMS-19, 21-27 ) were screened for their anti-inflammatory and anti-diabetic activity in different concentrations ( 20, 40, 80, 200 & 400 μg/mL ). The Diclofenac sodium and Acarbose were used as standard drugs for anti-inflammatory and anti-diabetic activities respectively. The 4-nitro-1 H -imidazoles (3a-i) and their protic imidazolium salts with ( E )-3-(4-hydroxy-3-methoxyphenyl)acrylate as an organic anion ( IMS-19, 21-27 ) are showed very good to remarkable anti-inflammatory and good to excellent anti-diabetic activities compared to their corresponding standard drug.