Expression of tripartite motif family-like protein 1 and 2 in early conceptus development and placentation in the pig

This study investigates the expression and possible roles of two specific proteins in pigs. These proteins are implicated in regulating inflammation and are thought to be important for the proper development of the placenta, which is essential for a successful pregnancy. TRIML2 was found in embryos and certain tissues, including ovary, testis and placenta, while TRIML1 appears only in the testis. We further used gene-editing techniques to generate pig embryos lacking these proteins to test whether their absence would affect early pregnancy and placental development. Lack of either TRIML1 or TRIML2 did not disrupt the early stages of pregnancy or placental formation, indicating that these proteins may not be critical for these processes in pigs.