Computational fluid dynamics model predictions of inhaled corticosteroid deposition in patients with severe asthma
In severe asthma patients with thicker airway walls, narrower airway lumens and elevated biomarkers of type-2 inflammation, a smaller ratio of ICS<sub>FP</sub> reached the peripheral airways. ICS<sub>EFP</sub> did not fully mitigate this. Patient-specific airway morphology may impact regional ICS deposition and contribute to persistent inflammation.
Authors
- Anna Dvorkin‐Gheva (ORCID: https://orcid.org/0000-0001-7295-7440)
- B.R. Lavon
- Carmen Venegas Garrido
- Myrna Dolovich (ORCID: https://orcid.org/0000-0002-3142-0281)
- A. Thakar
- Yonni Friedlander (ORCID: https://orcid.org/0000-0001-9399-7863)
- Nandhitha Ragunayakam
- Parameswaran Nair (ORCID: https://orcid.org/0000-0002-1041-9492)
- Sarah Svenningsen (ORCID: https://orcid.org/0000-0002-6225-1863)
- Kayla Zhang
- Manali Mukherjee (ORCID: https://orcid.org/0000-0002-7924-7211)
- Mark D. Inman (ORCID: https://orcid.org/0000-0003-4111-7654)
- Melanie Kjarsgaard
- Hosein Sadafi
Institutions
- Fluidda (United States) (US)
- St. Joseph’s Healthcare Hamilton (CA)
- McMaster University (CA)
Publication Details
- Journal
- Thorax
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1136/thorax-2024-222444
- Citations
- 2
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 3.04