DMoVGPE: predicting gut microbial associated metabolites profiles with deep mixture of variational Gaussian Process experts

Through extensive evaluations on various datasets, DMoVGPE consistently achieves higher prediction performance than existing models. Furthermore, our model reveals significant associations between specific microbial taxa and metabolites, aligning well with findings from existing studies. These results highlight DMoVGPE's potential to provide accurate predictions and to uncover biologically meaningful relationships, paving the way for its application in disease research and personalized healthcare strategies.

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Publication Details

Journal
BMC Bioinformatics
Published
2025-03-27
DOI
https://doi.org/10.1186/s12859-025-06110-7
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
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article

DMoVGPE: predicting gut microbial associated metabolites profiles with deep mixture of variational Gaussian Process experts

Jinlin Zhu, Guohao Peng, Qian Weng, Mingyi Hu
BMC Bioinformatics
Metabolomics and Mass Spectrometry Studies
article

DMoVGPE: predicting gut microbial associated metabolites profiles with deep mixture of variational Gaussian Process experts

Jinlin Zhu, Guohao Peng, Qian Weng, Mingyi Hu
article en

Abstract

Through extensive evaluations on various datasets, DMoVGPE consistently achieves higher prediction performance than existing models. Furthermore, our model reveals significant associations between specific microbial taxa and metabolites, aligning well with findings from existing studies. These results highlight DMoVGPE's potential to provide accurate predictions and to uncover biologically meaningful relationships, paving the way for its application in disease research and personalized healthcare strategies.

BMC BioinformaticsVol. 26(1)
Jiangnan University (CN), Nanyang Technological University (SG), State Key Laboratory of Food Science and Technology (CN)
Openalex Percentile: Top 95%
Metabolomics and Mass Spectrometry Studies
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DMoVGPE: predicting gut microbial associated metabolites profiles with deep mixture of variational Gaussian Process experts — Jinlin Zhu, Guohao Peng, et al. · BMC Bioinformatics (2025) | TGRS Research Map | TGRS