Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis
This extensive investigation identified several promising therapeutic targets for AKI and highlighted opportunities for drug repurposing. These findings offer valuable insights that could shape future research and the development of targeted treatments.
Authors
- Fei Deng (ORCID: https://orcid.org/0000-0002-9756-2557)
- Yinhuai Wang (ORCID: https://orcid.org/0000-0003-4731-0252)
- Dongfeng Zeng (ORCID: https://orcid.org/0000-0002-0460-7593)
- Shuiqing Wu (ORCID: https://orcid.org/0000-0002-1203-5580)
- Zebin Deng (ORCID: https://orcid.org/0000-0001-9509-211X)
- Jiachen Liu (ORCID: https://orcid.org/0000-0002-0263-3704)
Institutions
- Central South University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-03-27
- DOI
- https://doi.org/10.1186/s13062-025-00631-0
- Citations
- 5
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 7.15
Funders
- Natural Science Foundation of Hainan Province