Transbronchial Lung Cryobiopsy as a Diagnostic Tool for Gastric Cancer-induced Pulmonary Tumor Thrombotic Microangiopathy

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and frequently fatal complication associated with advanced gastric cancer, characterized by progressive dyspnea, pulmonary hypertension, and right heart failure. Diagnosing PTTM is challenging owing to its rapid progression and ability to mimic other respiratory conditions. Transbronchial lung cryobiopsy (TBLC) has recently emerged as a valuable diagnostic tool, providing larger and more intact tissue samples than conventional transbronchial lung biopsy (TBLB), which is often limited by tissue crush artifacts.