lncRNA EGOT Is the Marker of HPV Infection and a Prognostic Factor for HNSCC Patients
<b>Background:</b> High-risk human papillomavirus (HPV) contributes to oropharyngeal cancers through mechanisms involving the deregulation of host cell functions by oncoproteins E6 and E7. Changes in the epigenome, particularly involving long non-coding RNAs (lncRNAs), are crucial for understanding HPV-related carcinogenesis. <b>Methods:</b> This study aimed to analyze the expression levels of lncRNAs in HPV-related head and neck squamous cell carcinoma (HNSCC) to determine their biological and clinical significance, addressing the current gap in clinically validated biomarkers for early screening and therapeutic interventions. <b>Results:</b> The study highlights the significant overexpression of the <i>EGOT</i> gene in HPV-positive HNSCC samples, suggesting its potential as a marker to distinguish between HPV-negative and HPV-positive cases. Furthermore, high <i>EGOT</i> expression correlates with better overall survival (OS) and indicates possible resistance to therapy, making it a valuable prognostic factor. <b>Conclusions:</b> These findings underscore the potential of incorporating <i>EGOT</i> expression analysis in clinical practice for improved patient stratification and treatment outcomes in HNSCC.
Authors
- Ewa Leporowska (ORCID: https://orcid.org/0000-0001-5193-8697)
- Urszula Kazimierczak
- Jacek Mackiewicz (ORCID: https://orcid.org/0000-0002-0177-2972)
- Anna Przybyła (ORCID: https://orcid.org/0000-0002-6395-5731)
- Anna Teresiak (ORCID: https://orcid.org/0000-0002-5327-6698)
- Paulina Gieremek
- Maciej Stasiak (ORCID: https://orcid.org/0000-0002-5724-6373)
- Kacper Guglas (ORCID: https://orcid.org/0000-0002-2296-7808)
- Andrzej Maćkiewicz (ORCID: https://orcid.org/0000-0001-5574-6609)
- Zefiryn Cybulski (ORCID: https://orcid.org/0000-0002-7648-1520)
- Piotr Białas (ORCID: https://orcid.org/0000-0001-9133-4177)
- Marlena Janiczek-Polewska (ORCID: https://orcid.org/0000-0002-1238-5273)
- Paulina Poter (ORCID: https://orcid.org/0000-0003-1811-6901)
- Joanna Kozłowska-Masłoń (ORCID: https://orcid.org/0000-0001-6914-4852)
- Beata Stanisz (ORCID: https://orcid.org/0000-0003-4611-7039)
- Katarzyna Regulska (ORCID: https://orcid.org/0000-0002-9584-3128)
- Tomasz Kolenda (ORCID: https://orcid.org/0000-0001-5623-7398)
- Joanna Kazmierska
- Patrycja Mantaj
- Karina Tylkowska
- Anna Zapłata (ORCID: https://orcid.org/0009-0002-5611-1853)
Institutions
- Poznan University of Medical Sciences (PL)
- Greater Poland Cancer Center (PL)
- Adam Mickiewicz University in Poznań (PL)
Publication Details
- Journal
- Biomedicines
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3390/biomedicines13040798
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu