Dual role of calcium-activated potassium channels of high conductance: facilitator or limiter of NO-induced arterial relaxation?
BK<sub>Ca</sub> channels simultaneously limit NO-induced vasodilation at lower levels of contractility but facilitate it at higher levels of contractility in multiple vascular beds. Therefore, BK<sub>Ca</sub> channels may play a dual role as facilitators and as limiters of the effect of NO, depending on the level of contractility.
Authors
- Rudolf Schubert (ORCID: https://orcid.org/0000-0003-1777-1461)
- Dina K. Gaynullina (ORCID: https://orcid.org/0000-0001-5104-2399)
- Peter Winkler (ORCID: https://orcid.org/0000-0002-1259-3574)
- Anastasia A. Shvetsova (ORCID: https://orcid.org/0000-0001-8859-7689)
- Johannes Schmid (ORCID: https://orcid.org/0000-0001-8884-7924)
- Isabella Sonsala
Institutions
- University of Augsburg (DE)
- Lomonosov Moscow State University (RU)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Pirogov Russian National Research Medical University (RU)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fphys.2025.1563014
- Citations
- 1
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.81