Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion
Overall, we demonstrate that the transmembrane domain plays a critical role in CAR-T cell function. An optimized transmembrane domain can alleviate cytokine release syndrome and reduce CAR-T cell exhaustion, providing a direction for CAR design to enhance CAR-T cell function.
Authors
- Rufang Xiang (ORCID: https://orcid.org/0009-0005-3827-4714)
- Han Liu (ORCID: https://orcid.org/0000-0002-0022-1861)
- Zhenshu Xu (ORCID: https://orcid.org/0000-0002-4803-3990)
- Dan Li (ORCID: https://orcid.org/0000-0001-6458-6096)
- Wenjie Zhang (ORCID: https://orcid.org/0000-0001-6457-7800)
- Zhihong Chen (ORCID: https://orcid.org/0000-0002-1030-3289)
- Jinlan Long
- Ruiheng Wang (ORCID: https://orcid.org/0000-0002-4178-7511)
- Weiguang Dou
- Shufeng Xie
- Chunjun Zhao
- Ting Kang
- Yixin Wang (ORCID: https://orcid.org/0009-0002-3038-0692)
- Huajian Xian
Institutions
- Fujian Medical University (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- General Hospital of Guangzhou Military Command (CN)
- Shanghai Institute of Hematology (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1531344
- Citations
- 6
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 6.27