Estimating the incidence of actionable drug-gene interactions in Japanese patients with major depressive disorder

We estimated that one in four Japanese patients with major depressive disorder who were prescribed first-time antidepressants had actionable drug-gene interactions. These results suggest that pre-emptive pharmacogenetic testing in the treatment of major depressive disorder could have important clinical implications.

Authors

Masakazu Hatano (ORCID: https://orcid.org/0000-0001-7032-878X)
Nakao Iwata (ORCID: https://orcid.org/0000-0003-3189-6076)
Masami Miyata
Shigeki Yamada (ORCID: https://orcid.org/0000-0002-3891-1323)
Takeo Saito (ORCID: https://orcid.org/0000-0003-3671-4585)

Institutions

Fujita Health University (JP)
Nagoya University (JP)

Publication Details

Journal: Frontiers in Psychiatry
Published: 2025-03-27
DOI: https://doi.org/10.3389/fpsyt.2025.1542000
Citations: 2
Primary Topic: Treatment of Major Depression
Type: article
Field-Weighted Citation Impact: 2.79

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article

Estimating the incidence of actionable drug-gene interactions in Japanese patients with major depressive disorder

Masakazu Hatano, Nakao Iwata, Masami Miyata, Shigeki Yamada et al.

Mar 27, 2025

2 citations

Frontiers in Psychiatry

Treatment of Major Depression

2.79

article

Estimating the incidence of actionable drug-gene interactions in Japanese patients with major depressive disorder

Masakazu Hatano, Nakao Iwata, Masami Miyata, Shigeki Yamada, Takeo Saito

March 27, 2025article en

2 citations

Abstract

We estimated that one in four Japanese patients with major depressive disorder who were prescribed first-time antidepressants had actionable drug-gene interactions. These results suggest that pre-emptive pharmacogenetic testing in the treatment of major depressive disorder could have important clinical implications.

Frontiers in PsychiatryVol. 16

Fujita Health University (JP), Nagoya University (JP)

Good health and well-being

Openalex Percentile: Top 12%

Treatment of Major Depression

2.79

DOI Open Access PDF OpenAlex

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