Polarization of Vδ2 T cells to a Th2-like phenotype promotes plasmablast differentiation and possesses pro-fibrotic properties in IgG4-related disease
Within the IL-21-rich microenvironment of IgG4-RD, peripheral Vδ2 T cells acquire a Th2-like phenotype via the IL-21-STAT3-Blimp-1-GATA3 pathway. Targeting JAK/STAT3 inhibitors holds therapeutic potential for IgG4-RD.
Authors
- Linyi Peng (ORCID: https://orcid.org/0000-0002-7441-907X)
- Jiaxin Zhou (ORCID: https://orcid.org/0000-0002-1664-3495)
- Mu Wang (ORCID: https://orcid.org/0000-0002-3823-1272)
- Xiaofeng Zeng (ORCID: https://orcid.org/0000-0002-3883-2318)
- Yan Zhao (ORCID: https://orcid.org/0000-0003-4632-5647)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-7808-9867)
- Jieqiong Li (ORCID: https://orcid.org/0000-0001-8496-8614)
- Yunyun Fei (ORCID: https://orcid.org/0000-0003-1728-2342)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1550405
- Citations
- 1
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.67